cbinstitute pipelineAnimal’s models

Our projects are based on fundamental models and applied scientific problems studied on different preclinical models of diseases in animals: hypertension, IM, isoprenol heart failure and diabetes mellitus knock out the mouse, C6 Cancer. For animal research we use in vivo and in vitro methods for example: direct hemodynamic measurements, ischemia-reperfusion injury of the heart, blood pressure measurement (tail-cuff method), 24-hour blood pressure monitoring, plethysmographic measurement of experimental edema, real-time microcirculation- capillaroscopy (human nail fold and experimental animal mesentery) isolated perfused heart (Langendorff preparation), evaluation of contractile activity of atria, blood vessels (aorta, small mesenteric arteries) and trachea, sciatic nerve of rats, standard histological methods, immunohistochemistry, picture analysis, isolated cardiac myocytes – fractional shortening, determination of circulating endothelial cells biochemical measurements (cholesterol, lipids, glucose  etc.)

Molecular biology

Molecular biology is primarily concerned with understanding and the interactions between the various systems of a cell, including the interactions between the different types of DNA, RNA and protein biosynthesis as well as learning how these interactions are regulated.

Methods used in our research of molecular biology:

  • DNA, RNA, isolation, determination, and electrophoresis
  • PCR (classic and real-time detection)
  • Western blot (chemiluminescent detection)


Medical imaging is the technique and process used to create images of the human body, tissues or cells for clinical purposes or medical science.

Methods used in our research of biomedicine imaging include:

  • Fluorescence diagnostics of cells and tissues in physiological conditions and during pharmacological treatment
  • Development of biosensors, encapsulation of biologically active molecules and nanoscale substances using defined polymer membranes for biotechnology and biomedicine
  • Pulsed laser polymerization and study of complex physical systems using optical methods.

The primary purpose of our research is to search for knowledge and with any the systematic investigation we search with an open mind to establish novel facts, to solve new or existing problems, to prove new ideas, and develop new theories using the scientific methods.

Our expertise fields in research and development:

  • Experimental pharmacology
  • Molecular biology
  • Chemical modelling
  • Chemical synthesis
  • Chemical analysis
  • Biophysics Clinical
  • Pharmacology

Our research is applied and developed using the reliable and time tested theories and ideas of the research community along with our own knowledge, methods, and techniques, for a specific commercial purpose.

We can provide for our customers applied research on the following fields:

Stem cells research and clinical therapy
Antibodies discovery and producing
Imaging- applications in biomedicine research
Diagnostics- molecular, genetically and tissue determination
New molecules- from computer modelling through chemical synthesis to experimental models testing
Clinical trials – cell therapy, new molecules, statistical analyses
Administrative for EMEA – writing of applications, assessment results of trials.